Elucidating the mechanism of cellular uptake and sioux falls dating services


09-Nov-2019 16:31

elucidating the mechanism of cellular uptake and-52

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Although the mechanism of action of biguanides remains imperfectly understood the efficacy of metformin in the treatment of type 2 diabetes is unchallenged.

Two promising methods employed to this end include functionalization of m NPs with cell-penetrating peptides to promote efficient translocation of cargo into the cell and the use of external magnetic fields for enhanced delivery.Magnetic NPs (m NPs), such as superparamagnetic iron oxide nanoparticles (Fe), are of such a size that they are easily magnetised under an applied field, but lose their magnetism as soon as the magnetic field is removed (thus preventing NP aggregation), and provide an excellent platform for use in clinic.Currently m NPs are employed in clinic in MRI, which allows intra-tissue and intracellular detection.In this thesis, we provide for the first time ever evidence for biguanides binding directly a cytosolic protein, Coronin1C.

elucidating the mechanism of cellular uptake and-1

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This study provides evidence that biguanides may indeed antagonize the action of glucagon, thus reducing fasting glucose levels, through modulation of Coronin1C.

Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha, 410082, China. Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha, 410082, China. Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha, 410082, China. Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha, 410082, China. Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha, 410082, China. Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha, 410082, China.



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